Collaborations

 

Dr. Robert H. Grubbs PhD, Caltech

In collaboration with Dr. Grubbs at Caltech, we are developing a new minimally invasive technique to potentially replace routine endourologic techniques to treat urinary stones. Injection of our specialized tagged bubbles will attach to the offending stone/s and with appropriate energy sources will cavitate and fracture the stones. Proof of concept with high speed photography was performed with collaborators at the University of Washington. Patents have been issued (US2013/0123781) and we are in active discussions with various companies to develop a commercial application.  Read More.....

Bard Medical

Bard Medical provides medical supplies for urology and incontinence treatment.  A delegation of Urologists from China were here to meet with Drs. Stoller and Chi and their respective clinical groups in an exchange of information and surgical techniques.  They also engaged in discussion on future collaborative research and clinical study ideas focusing on the field of Urinary Stone Disease. Read more......

San Francisco Firefighters Cancer Prevention Foundation

Flame retardants are a diverse group of chemicals that have been used extensively in clothing, insulation, plastics, and a host of other manufactured materials to inhibit combustion or spreading of the fire. The ubiquitous use of these chemicals has resulted in widespread exposure within most developed countries. In fact, nearly all Americans tested have measurable levels of flame retardants in blood or urine. Exposure to these chemicals has been associated with poor pregnancy outcomes, abnormal fetal development, altered thyroid function, neurodegeneration, and even certain cancers. Read More.....

Dr. Pankaj Kapahi, The Buck Institute for Research on Aging

Drs. Stoller, Chi and Kapahi have been working together for several years now developing a novel model for the study of urinary stones and for the first time demonstrate a genetic screen to effectively identify suppressors of stone formation using Drosophila melanogaster (the fruit fly). Dr. Kapahi's expertise in using this fly model to study how various physiological and molecular processes, including the role of calcification, are influenced by nutrients to impact organismal health and survival is integral to their combined research activities. His work has relevance to a number of age-related human diseases including diabetes, kidney stone formation, intestinal diseases, cancer and obesity.  Read More......

Dr. David Killilea, Children's Hospital Oakland Research Institute (CHORI)

Metals have fundamental roles within human metabolism. Nutritional metals are tightly regulated by coordinated molecular and cellular responses, but imbalances can persist and lead to chronic disease. Conversely, toxic metals can disrupt metabolism by masquerading as nutritional metals but with aberrant binding or regulatory effect. Therefore, Dr. Killilea’s group is focused on developing novel, sensitive biomarkers to better understand the pharmacodynamics of key metals and reveal new targets for disease intervention.  Read More.....

Dr. Sunita Ho, UCSF School of Dentistry

Drs. Marshall Stoller and Thomas Chi and their research and clinical teams have formed a collaboration with Dr. Sunita Ho of the UCSF School of Dentistry.  Dr. Ho has helped spearhead studies onthe micor architecture of human calculi.  Read More......

Dr. Jodi Westropp DVM PhD, University of California, Davis Veterinary Medicine

Dr. Westropp has joined up with Drs. Stoller and Chi as she investigates randall plaques in the kidneys and analysis of calcified nanaoparticles in the urine and blood in cats and dog with calcium oxalate urolithiasis. Her expertise in this subject and utilizing techniques on her animal model add depth to the non-clinical studies being conducted by the Stoller-Chi research team.  Read More.....

Dr. Daryl Chrzan, University of California, Berkeley

Dr. Daryl Chrzan is a faculty member in the department of material science at UC Berkeley. He is working with Drs. Stoller and Chi on a model that changes crystal structure when selenium is replaced with sulphur in cystine stones. He is also helping the research group understand why they see lucent spaces at the center of small nano-calculi.  Read More......

EDDA Technology

EDDA Technology ("EDDA") is an innovative computer solution provider in the rapidly emerging field of Computer Assisted Radiology and Surgery. EDDA's product IQQA-Guide (FDA cleared K151414) combines the IQQA quantitative modeling from 3D images, eletromagnetic tracking, and information fusion technology to support intra-operative guidance for surgical procedures.  EDDA intends to further the clinical application of IQQA-Guide to urologic interventional treatment.  Read More.....

Medsonics US, Inc

Medsonics US, Inc. is developing and will commercialize a lightweight, portable and economical line of highly versatile non-invasive advanced medical ultrasound diagnostic devices. They serve the clinical area of quantitative bone monitoring of fractures and strength. This patented technology will safely furnish, in real time, information on fracture status from inception to full healing. Read More....