Applaud Medical, Inc., a clinical-stage company based in San Francisco, is committed to improving patient outcomes with innovative new products and procedures built around its SmartSphere technology platform. Two SmartSphere products for urinary stone disease are currently in clinical trials. SmartSphere products are not approved for sale in the United States.

Pathogenesis of Urinary Stone Disease

Novel insights into renal mineralization and stone formation through advanced imaging modalities.

Wiener SV1, Chen L2, Shimotake AR2, Kang M2, Stoller ML1, Ho SP1,2.
Connect Tissue Res. 2018 Dec;59(sup1):102-110. doi: 10.1080/03008207.2017.1409219.
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Architecture-Guided Fluid Flow Directs Renal Biomineralization.

Ho SP1,2, Chen L3, Allen FI4,5, Hsi RS6, Shimotake AR3, Wiener SV7, Kang M3, Minor AM4,5, Stoller ML7.
Sci Rep. 2018 Sep 21;8(1):14157. doi: 10.1038/s41598-018-30717-x.
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A continuum of mineralization from human renal pyramid to stones on stems.

Sherer BA1, Chen L2, Kang M2, Shimotake AR2, Wiener SV1, Chi T1, Stoller ML1, Ho SP3.
Acta Biomater. 2018 Apr 15;71:72-85. doi: 10.1016/j.actbio.2018.01.040. Epub 2018 Feb 9.
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The origins of urinary stone disease: upstream mineral formations initiate downstream Randall's plaque.

Hsi RS1, Ramaswamy K1, Ho SP2, Stoller ML1.
BJU Int. 2017 Jan; 119(1):177-184. doi: 10.1111/bju.13555. Epub 2016 Jul 14.
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Created by leading specialists, Moonstone is the only patented citrate product that works with the body’s chemistry to support daily kidney health.

Available here, CVS & Amazon